BDBM14446 2-quinolone analog 22::4-{[(1-{[4-(3-chlorophenyl)-1-methyl-2-oxo-1,2-dihydroquinolin-6-yl]methyl}-1H-imidazol-5-yl)methoxy]methyl}benzonitrile

SMILES: Cn1c2ccc(Cn3cncc3COCc3ccc(cc3)C#N)cc2c(cc1=O)-c1cccc(Cl)c1

InChI Key: InChIKey=WNSRXUXASWLVPX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 14446   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM14446 (2-quinolone analog 22 | 4-{[(1-{[4-(3-chlorophenyl...) Show SMILES Cn1c2ccc(Cn3cncc3COCc3ccc(cc3)C#N)cc2c(cc1=O)-c1cccc(Cl)c1 Show InChI InChI=1S/C29H23ClN4O2/c1-33-28-10-9-22(11-27(28)26(13-29(33)35)23-3-2-4-24(30)12-23)16-34-19-32-15-25(34)18-36-17-21-7-5-20(14-31)6-8-21/h2-13,15,19H,16-18H2,1H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	7.5	37
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...				Bioorg Med Chem Lett 15: 2033-9 (2005) Article DOI: 10.1016/j.bmcl.2005.02.062 BindingDB Entry DOI: 10.7270/Q23J3B61
					More data for this Ligand-Target Pair