BDBM14447 2-quinolone analog 24::4-(3-chlorophenyl)-1-methyl-6-({5-[(4-oxo-1,4-dihydropyridin-1-yl)methyl]-1H-imidazol-1-yl}methyl)-1,2-dihydroquinolin-2-one
SMILES: Cn1c2ccc(Cn3cncc3Cn3ccc(=O)cc3)cc2c(cc1=O)-c1cccc(Cl)c1
InChI Key: InChIKey=IBAVHLSMEQFZPY-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein Farnesyltransferase (PFT) (Bos taurus (bovine)) | BDBM14447 (2-quinolone analog 24 | 4-(3-chlorophenyl)-1-methy...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Abbott Laboratories | Assay Description The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r... | Bioorg Med Chem Lett 15: 2033-9 (2005) Article DOI: 10.1016/j.bmcl.2005.02.062 BindingDB Entry DOI: 10.7270/Q23J3B61 | |||||||||||
More data for this Ligand-Target Pair |