BDBM144487 US8969568, 39

SMILES: COc1cc(cc(OC)c1OC)-c1cc2ncccc2c(N[C@H](C)[C@H]2CNC(=O)C2)n1

InChI Key: InChIKey=SOIJWEWGKXPXPV-UKRRQHHQSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 144487   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM144487 (US8969568, 39) Show SMILES COc1cc(cc(OC)c1OC)-c1cc2ncccc2c(N[C@H](C)[C@H]2CNC(=O)C2)n1 |r| Show InChI InChI=1S/C23H26N4O4/c1-13(15-10-21(28)25-12-15)26-23-16-6-5-7-24-18(16)11-17(27-23)14-8-19(29-2)22(31-4)20(9-14)30-3/h5-9,11,13,15H,10,12H2,1-4H3,(H,25,28)(H,26,27)/t13-,15-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13.3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH & Co. KG US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US8969568 (2015) BindingDB Entry DOI: 10.7270/Q2154FRD
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