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SMILES: COc1ccc(cc1OC)-c1cc2ncccc2c(NCc2n[nH]c(=O)o2)n1

InChI Key: InChIKey=NCVAOMFPAFGONW-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 144514   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM144514 (US8969568, 67) Show SMILES COc1ccc(cc1OC)-c1cc2ncccc2c(NCc2n[nH]c(=O)o2)n1 Show InChI InChI=1S/C19H17N5O4/c1-26-15-6-5-11(8-16(15)27-2)13-9-14-12(4-3-7-20-14)18(22-13)21-10-17-23-24-19(25)28-17/h3-9H,10H2,1-2H3,(H,21,22)(H,24,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH & Co. KG US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US8969568 (2015) BindingDB Entry DOI: 10.7270/Q2154FRD
					More data for this Ligand-Target Pair