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BDBM144676 US8952037, 49

SMILES: Cc1ncccc1-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1

InChI Key: InChIKey=QTZTWQRKTZMASJ-GASCZTMLSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 144676   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM144676
PNG
(US8952037, 49)
Show SMILES Cc1ncccc1-c1nccnc1O[C@@H]1C[C@@H](C1)Nc1nc2ccccc2s1 |r,wU:14.15,16.20,(-3.32,.77,;-4.65,1.54,;-4.65,3.08,;-5.98,3.85,;-7.32,3.08,;-7.32,1.54,;-5.98,.77,;-5.98,-.77,;-7.32,-1.54,;-7.32,-3.08,;-5.98,-3.85,;-4.65,-3.08,;-4.65,-1.54,;-3.32,-.77,;-1.98,-1.54,;-1.58,-3.03,;-.1,-2.63,;-.5,-1.14,;1.24,-3.4,;2.57,-2.63,;2.73,-1.1,;4.24,-.78,;5.01,.56,;6.55,.56,;7.32,-.78,;6.55,-2.11,;5.01,-2.11,;3.98,-3.26,)|
Show InChI InChI=1S/C21H19N5OS/c1-13-16(5-4-8-22-13)19-20(24-10-9-23-19)27-15-11-14(12-15)25-21-26-17-6-2-3-7-18(17)28-21/h2-10,14-15H,11-12H2,1H3,(H,25,26)/t14-,15+
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Similars
US Patent
n/an/a 1.94n/an/an/an/an/a25



Amgen Inc.

US Patent


Assay Description
Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL, of serial diluted P...

US Patent US8952037 (2015)


BindingDB Entry DOI: 10.7270/Q23X85CW
More data for this
Ligand-Target Pair