BDBM14519 N-[(4-carbamimidoylphenyl)methyl]-2-(5-chloro-3-{[2-(4-chlorophenyl)ethyl]amino}-2-oxo-6-phenyl-1,2-dihydropyrazin-1-yl)acetamide::Pyrazinone Analog 26f

SMILES: NC(=N)c1ccc(CNC(=O)Cn2c(c(Cl)nc(NCCc3ccc(Cl)cc3)c2=O)-c2ccccc2)cc1

InChI Key: InChIKey=UOBNDUHIJFVGQQ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 14519   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor VII (Homo sapiens (Human))	BDBM14519 (N-[(4-carbamimidoylphenyl)methyl]-2-(5-chloro-3-{[...) Show SMILES NC(=N)c1ccc(CNC(=O)Cn2c(c(Cl)nc(NCCc3ccc(Cl)cc3)c2=O)-c2ccccc2)cc1 Show InChI InChI=1S/C28H26Cl2N6O2/c29-22-12-8-18(9-13-22)14-15-33-27-28(38)36(24(25(30)35-27)20-4-2-1-3-5-20)17-23(37)34-16-19-6-10-21(11-7-19)26(31)32/h1-13H,14-17H2,(H3,31,32)(H,33,35)(H,34,37)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia Corporation					Assay Description Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...				J Med Chem 46: 4050-62 (2003) Article DOI: 10.1021/jm030131l BindingDB Entry DOI: 10.7270/Q2FT8J9M
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM14519 (N-[(4-carbamimidoylphenyl)methyl]-2-(5-chloro-3-{[...) Show SMILES NC(=N)c1ccc(CNC(=O)Cn2c(c(Cl)nc(NCCc3ccc(Cl)cc3)c2=O)-c2ccccc2)cc1 Show InChI InChI=1S/C28H26Cl2N6O2/c29-22-12-8-18(9-13-22)14-15-33-27-28(38)36(24(25(30)35-27)20-4-2-1-3-5-20)17-23(37)34-16-19-6-10-21(11-7-19)26(31)32/h1-13H,14-17H2,(H3,31,32)(H,33,35)(H,34,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	<40	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia Corporation					Assay Description Human thrombin and substrate were added to a 96-well assay plate containing inhibitor in reaction buffer. The rate of hydrolysis of the substrate was...				J Med Chem 46: 4050-62 (2003) Article DOI: 10.1021/jm030131l BindingDB Entry DOI: 10.7270/Q2FT8J9M
					More data for this Ligand-Target Pair