null

SMILES: CCc1cc(C(=O)NS(=O)(=O)N2CCC2)c(F)cc1OCC12CC3CC(CC(C3)C1)C2

InChI Key: InChIKey=HGORKEAQBNUKLZ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 145267   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145267 (US8952169, 46) Show SMILES CCc1cc(C(=O)NS(=O)(=O)N2CCC2)c(F)cc1OCC12CC3CC(CC(C3)C1)C2 |TLB:30:21:28:24.25.26,THB:20:21:28:24.25.26,30:25:28:21.29.22,29:21:24:28.27.26,29:27:24:21.30.22| Show InChI InChI=1S/C23H31FN2O4S/c1-2-18-9-19(22(27)25-31(28,29)26-4-3-5-26)20(24)10-21(18)30-14-23-11-15-6-16(12-23)8-17(7-15)13-23/h9-10,15-17H,2-8,11-14H2,1H3,(H,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145267 (US8952169, 46) Show SMILES CCc1cc(C(=O)NS(=O)(=O)N2CCC2)c(F)cc1OCC12CC3CC(CC(C3)C1)C2 |TLB:30:21:28:24.25.26,THB:20:21:28:24.25.26,30:25:28:21.29.22,29:21:24:28.27.26,29:27:24:21.30.22| Show InChI InChI=1S/C23H31FN2O4S/c1-2-18-9-19(22(27)25-31(28,29)26-4-3-5-26)20(24)10-21(18)30-14-23-11-15-6-16(12-23)8-17(7-15)13-23/h9-10,15-17H,2-8,11-14H2,1H3,(H,25,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	25
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair