BDBM145270 US8952169, 49

SMILES: COCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F

InChI Key: InChIKey=AADZPNRBAZVGNN-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 145270   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145270 (US8952169, 49) Show SMILES COCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F |TLB:28:19:26:22.23.24,THB:18:19:26:22.23.24,28:23:26:19.27.20,27:19:22:26.25.24,27:25:22:19.28.20| Show InChI InChI=1S/C24H32FNO5S/c1-30-4-5-32(28,29)26-23(27)20-9-19(18-2-3-18)22(10-21(20)25)31-14-24-11-15-6-16(12-24)8-17(7-15)13-24/h9-10,15-18H,2-8,11-14H2,1H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	25
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145270 (US8952169, 49) Show SMILES COCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F |TLB:28:19:26:22.23.24,THB:18:19:26:22.23.24,28:23:26:19.27.20,27:19:22:26.25.24,27:25:22:19.28.20| Show InChI InChI=1S/C24H32FNO5S/c1-30-4-5-32(28,29)26-23(27)20-9-19(18-2-3-18)22(10-21(20)25)31-14-24-11-15-6-16(12-24)8-17(7-15)13-24/h9-10,15-18H,2-8,11-14H2,1H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM145270 (US8952169, 49) Show SMILES COCCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(C4)C2)C3)cc1F |TLB:28:19:26:22.23.24,THB:18:19:26:22.23.24,28:23:26:19.27.20,27:19:22:26.25.24,27:25:22:19.28.20| Show InChI InChI=1S/C24H32FNO5S/c1-30-4-5-32(28,29)26-23(27)20-9-19(18-2-3-18)22(10-21(20)25)31-14-24-11-15-6-16(12-24)8-17(7-15)13-24/h9-10,15-18H,2-8,11-14H2,1H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	101	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair