BDBM145377 US8952169, 156

SMILES: CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(F)(C4)C2)C3)cc1F

InChI Key: InChIKey=IIPWDUUWYVPIFQ-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 145377   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145377 (US8952169, 156) Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC23CC4CC(CC(F)(C4)C2)C3)cc1F |TLB:15:16:21:24.18.19,26:16:24:21.20.19,THB:17:16:21:24.18.19,17:18:21:16.26.25,26:20:24:16.17.25| Show InChI InChI=1S/C22H27F2NO4S/c1-30(27,28)25-20(26)17-5-16(15-2-3-15)19(6-18(17)23)29-12-21-7-13-4-14(8-21)10-22(24,9-13)11-21/h5-6,13-15H,2-4,7-12H2,1H3,(H,25,26)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	25
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
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