BDBM145411 US8952169, 190

SMILES: CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2C3CC4CC(C3)CC2C4)cc1F

InChI Key: InChIKey=OKLUDWZPBLYJJR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 145411   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145411 (US8952169, 190) Show SMILES CS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2C3CC4CC(C3)CC2C4)cc1F |TLB:15:16:18:20.21.22,THB:23:24:18:20.21.22,23:21:18:24.25.16,16:24:20:18.17.22,16:17:20:24.23.25,(7.75,1.73,;6.42,2.5,;5.65,3.84,;7.19,3.84,;5.08,1.73,;3.75,2.5,;3.75,4.04,;2.41,1.73,;2.41,.19,;1.08,-.58,;1.08,-2.12,;.31,-3.45,;1.85,-3.45,;-.25,.19,;-1.59,-.58,;-2.92,.19,;-4.25,-.58,;-5.58,.19,;-6.92,-.58,;-6.92,-2.12,;-7.75,-4.02,;-6.35,-3.37,;-6.34,-.97,;-5.15,-4.04,;-4.25,-2.12,;-5.58,-2.89,;-.25,1.73,;1.08,2.5,;1.08,4.04,)| Show InChI InChI=1S/C22H28FNO4S/c1-29(26,27)24-22(25)18-9-17(14-2-3-14)21(10-20(18)23)28-11-19-15-5-12-4-13(7-15)8-16(19)6-12/h9-10,12-16,19H,2-8,11H2,1H3,(H,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	7.4	25
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
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