BDBM145481 US8952169, 262

SMILES: Fc1cc(OCC23CC4CC(C2)C(F)(F)C(C4)C3)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1

InChI Key: InChIKey=ADMLHCZRKYFTCM-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 145481   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145481 (US8952169, 262) Show SMILES Fc1cc(OCC23CC4CC(C2)C(F)(F)C(C4)C3)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1 |TLB:5:6:9:12.15.16,THB:17:6:9:12.15.16,17:15:9:6.7.11,7:6:12:9.8.16,7:8:12:6.17.11| Show InChI InChI=1S/C24H28F3NO4S/c25-20-8-21(32-12-23-9-13-5-15(10-23)24(26,27)16(6-13)11-23)18(14-1-2-14)7-19(20)22(29)28-33(30,31)17-3-4-17/h7-8,13-17H,1-6,9-12H2,(H,28,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	25
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145481 (US8952169, 262) Show SMILES Fc1cc(OCC23CC4CC(C2)C(F)(F)C(C4)C3)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1 |TLB:5:6:9:12.15.16,THB:17:6:9:12.15.16,17:15:9:6.7.11,7:6:12:9.8.16,7:8:12:6.17.11| Show InChI InChI=1S/C24H28F3NO4S/c25-20-8-21(32-12-23-9-13-5-15(10-23)24(26,27)16(6-13)11-23)18(14-1-2-14)7-19(20)22(29)28-33(30,31)17-3-4-17/h7-8,13-17H,1-6,9-12H2,(H,28,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM145481 (US8952169, 262) Show SMILES Fc1cc(OCC23CC4CC(C2)C(F)(F)C(C4)C3)c(cc1C(=O)NS(=O)(=O)C1CC1)C1CC1 |TLB:5:6:9:12.15.16,THB:17:6:9:12.15.16,17:15:9:6.7.11,7:6:12:9.8.16,7:8:12:6.17.11| Show InChI InChI=1S/C24H28F3NO4S/c25-20-8-21(32-12-23-9-13-5-15(10-23)24(26,27)16(6-13)11-23)18(14-1-2-14)7-19(20)22(29)28-33(30,31)17-3-4-17/h7-8,13-17H,1-6,9-12H2,(H,28,29)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair