BDBM145485 US8952169, 269

SMILES: Fc1cc(OCC23CC2CCCC3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1

InChI Key: InChIKey=KDOYGXBJAYKYQW-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 145485   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145485 (US8952169, 269) Show SMILES Fc1cc(OCC23CC2CCCC3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 Show InChI InChI=1S/C21H27FN2O4S/c22-18-11-19(28-13-21-7-2-1-4-15(21)12-21)16(14-5-6-14)10-17(18)20(25)23-29(26,27)24-8-3-9-24/h10-11,14-15H,1-9,12-13H2,(H,23,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	7.4	25
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145485 (US8952169, 269) Show SMILES Fc1cc(OCC23CC2CCCC3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 Show InChI InChI=1S/C21H27FN2O4S/c22-18-11-19(28-13-21-7-2-1-4-15(21)12-21)16(14-5-6-14)10-17(18)20(25)23-29(26,27)24-8-3-9-24/h10-11,14-15H,1-9,12-13H2,(H,23,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 5 subunit alpha (Homo sapiens (Human))	BDBM145485 (US8952169, 269) Show SMILES Fc1cc(OCC23CC2CCCC3)c(cc1C(=O)NS(=O)(=O)N1CCC1)C1CC1 Show InChI InChI=1S/C21H27FN2O4S/c22-18-11-19(28-13-21-7-2-1-4-15(21)12-21)16(14-5-6-14)10-17(18)20(25)23-29(26,27)24-8-3-9-24/h10-11,14-15H,1-9,12-13H2,(H,23,25)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair