BDBM145609 US8952169, 412

SMILES: CCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCC3(CC3)CC2)cc1F

InChI Key: InChIKey=HEUVLYHJGIMASW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 145609   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145609 (US8952169, 412) Show SMILES CCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCC3(CC3)CC2)cc1F Show InChI InChI=1S/C21H28FNO4S/c1-2-28(25,26)23-20(24)17-11-16(15-3-4-15)19(12-18(17)22)27-13-14-5-7-21(8-6-14)9-10-21/h11-12,14-15H,2-10,13H2,1H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145609 (US8952169, 412) Show SMILES CCS(=O)(=O)NC(=O)c1cc(C2CC2)c(OCC2CCC3(CC3)CC2)cc1F Show InChI InChI=1S/C21H28FNO4S/c1-2-28(25,26)23-20(24)17-11-16(15-3-4-15)19(12-18(17)22)27-13-14-5-7-21(8-6-14)9-10-21/h11-12,14-15H,2-10,13H2,1H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.4	25
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair