BDBM145739 US8952177, 93::US9089569, 93::US9695149, 93

SMILES: Cn1ccc(COc2cc(F)c3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4)c3c2)n1

InChI Key: InChIKey=QTVAJPZZLCMONG-RTWAWAEBSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 145739   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145739 (US8952177, 93 | US9089569, 93 | US9695149, 93) Show SMILES Cn1ccc(COc2cc(F)c3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4)c3c2)n1 |r| Show InChI InChI=1S/C26H26BrFN4O3/c1-31-11-10-18(30-31)15-35-19-12-22(28)24-23(13-19)32(14-16-6-8-17(27)9-7-16)25(29-24)20-4-2-3-5-21(20)26(33)34/h6-13,20-21H,2-5,14-15H2,1H3,(H,33,34)/t20-,21+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...				US Patent US8952177 (2015) BindingDB Entry DOI: 10.7270/Q2G73CFW
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145739 (US8952177, 93 | US9089569, 93 | US9695149, 93) Show SMILES Cn1ccc(COc2cc(F)c3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4)c3c2)n1 |r| Show InChI InChI=1S/C26H26BrFN4O3/c1-31-11-10-18(30-31)15-35-19-12-22(28)24-23(13-19)32(14-16-6-8-17(27)9-7-16)25(29-24)20-4-2-3-5-21(20)26(33)34/h6-13,20-21H,2-5,14-15H2,1H3,(H,33,34)/t20-,21+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9695149 (2017) BindingDB Entry DOI: 10.7270/Q2Q52MSC
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145739 (US8952177, 93 | US9089569, 93 | US9695149, 93) Show SMILES Cn1ccc(COc2cc(F)c3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4)c3c2)n1 |r| Show InChI InChI=1S/C26H26BrFN4O3/c1-31-11-10-18(30-31)15-35-19-12-22(28)24-23(13-19)32(14-16-6-8-17(27)9-7-16)25(29-24)20-4-2-3-5-21(20)26(33)34/h6-13,20-21H,2-5,14-15H2,1H3,(H,33,34)/t20-,21+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9089569 (2015) BindingDB Entry DOI: 10.7270/Q23X85DB
					More data for this Ligand-Target Pair