BDBM145901 US8957064, 38.0

SMILES: Cc1cn2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CC(C2)c2n[nH]c(n2)-c2cccc(C)n2)cc1

InChI Key: InChIKey=CIRLUEPNSNWHDA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 145901   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM145901 (US8957064, 38.0) Show SMILES Cc1cn2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CC(C2)c2n[nH]c(n2)-c2cccc(C)n2)cc1 Show InChI InChI=1S/C31H28N8/c1-20-7-6-10-27(32-20)30-35-29(36-37-30)25-17-38(18-25)16-22-11-13-24(14-12-22)28-26(23-8-4-3-5-9-23)19-39-15-21(2)33-31(39)34-28/h3-15,19,25H,16-18H2,1-2H3,(H,35,36,37)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.5	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Akt1 inhibitory activity of compounds of the present invention may be quantified0 employing the Akt1 TR-FRET assay as described in the following para...				US Patent US8957064 (2015) BindingDB Entry DOI: 10.7270/Q2Z60MRP
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM145901 (US8957064, 38.0) Show SMILES Cc1cn2cc(-c3ccccc3)c(nc2n1)-c1ccc(CN2CC(C2)c2n[nH]c(n2)-c2cccc(C)n2)cc1 Show InChI InChI=1S/C31H28N8/c1-20-7-6-10-27(32-20)30-35-29(36-37-30)25-17-38(18-25)16-22-11-13-24(14-12-22)28-26(23-8-4-3-5-9-23)19-39-15-21(2)33-31(39)34-28/h3-15,19,25H,16-18H2,1-2H3,(H,35,36,37)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	7.5	n/a
Bayer Intellectual Property GmbH US Patent					Assay Description Akt2 inhibitory activity of compounds of the present invention was quantified employing the Akt2 TR-FRET assay as described in the following paragrap...				US Patent US8957064 (2015) BindingDB Entry DOI: 10.7270/Q2Z60MRP
					More data for this Ligand-Target Pair