BDBM146918 US8957073, 28.17

SMILES: OCC1CCN(CC1)c1nccnc1C1CN(C1)c1cnc2ccc(Cl)cc2n1

InChI Key: InChIKey=MQBKZSQJWGEDOC-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 146918   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM146918 (US8957073, 28.17) Show SMILES OCC1CCN(CC1)c1nccnc1C1CN(C1)c1cnc2ccc(Cl)cc2n1 Show InChI InChI=1S/C21H23ClN6O/c22-16-1-2-17-18(9-16)26-19(10-25-17)28-11-15(12-28)20-21(24-6-5-23-20)27-7-3-14(13-29)4-8-27/h1-2,5-6,9-10,14-15,29H,3-4,7-8,11-13H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	25
Amgen Inc. US Patent					Assay Description Enzyme Activity. An IMAP TR-FRET assay was used to analyze the enzyme activity (Molecular Devices Corp., Sunnyvale Calif.). 5 uL of serial diluted PD...				US Patent US8957073 (2015) BindingDB Entry DOI: 10.7270/Q2PR7TPZ
					More data for this Ligand-Target Pair