Found 4 hits for monomerid = 147139 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A
(Homo sapiens (Human)) | BDBM147139
(US8957077, 1-9)Show InChI InChI=1S/C15H17N5S/c1-9-13(21-10(2)18-9)8-16-15-7-12(11-3-4-11)19-14-5-6-17-20(14)15/h5-7,11,16H,3-4,8H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| 9.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exper... |
US Patent US8957077 (2015)
BindingDB Entry DOI: 10.7270/Q29G5KHW |
More data for this Ligand-Target Pair | |
3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM147139
(US8957077, 1-9)Show InChI InChI=1S/C15H17N5S/c1-9-13(21-10(2)18-9)8-16-15-7-12(11-3-4-11)19-14-5-6-17-20(14)15/h5-7,11,16H,3-4,8H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 9.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of PDE10A (unknown origin) by IMAP assay |
Bioorg Med Chem Lett 26: 126-32 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.013 BindingDB Entry DOI: 10.7270/Q2NP27FW |
More data for this Ligand-Target Pair | |
Pregnane X receptor
(Homo sapiens (Human)) | BDBM147139
(US8957077, 1-9)Show InChI InChI=1S/C15H17N5S/c1-9-13(21-10(2)18-9)8-16-15-7-12(11-3-4-11)19-14-5-6-17-20(14)15/h5-7,11,16H,3-4,8H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | >2.50E+5 | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Activation of PXR (unknown origin) |
Bioorg Med Chem Lett 26: 126-32 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.013 BindingDB Entry DOI: 10.7270/Q2NP27FW |
More data for this Ligand-Target Pair | |
Cytochrome P450 3A4
(Homo sapiens (Human)) | BDBM147139
(US8957077, 1-9)Show InChI InChI=1S/C15H17N5S/c1-9-13(21-10(2)18-9)8-16-15-7-12(11-3-4-11)19-14-5-6-17-20(14)15/h5-7,11,16H,3-4,8H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description Inhibition of CYP3A4 (unknown origin) |
Bioorg Med Chem Lett 26: 126-32 (2016)
Article DOI: 10.1016/j.bmcl.2015.11.013 BindingDB Entry DOI: 10.7270/Q2NP27FW |
More data for this Ligand-Target Pair | |