BDBM147140 US8957077, 1-10

SMILES: COc1ccc(CCCCc2cc(NCc3sc(C)nc3C)n3nccc3n2)nc1

InChI Key: InChIKey=VGMNDWIPJRWIHH-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 147140   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM147140 (US8957077, 1-10) Show SMILES COc1ccc(CCCCc2cc(NCc3sc(C)nc3C)n3nccc3n2)nc1 Show InChI InChI=1S/C22H26N6OS/c1-15-20(30-16(2)26-15)14-24-22-12-18(27-21-10-11-25-28(21)22)7-5-4-6-17-8-9-19(29-3)13-23-17/h8-13,24H,4-7,14H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.370	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exper...				US Patent US8957077 (2015) BindingDB Entry DOI: 10.7270/Q29G5KHW
					More data for this Ligand-Target Pair