BDBM147146 US8957077, 1-23

SMILES: Cc1nc(C)c(CNc2cc(nc3ccnn23)C(=O)NC[C@H]2C[C@@H]2c2ccc3ccccc3n2)s1

InChI Key: InChIKey=NENPLIYVPALBEY-MOPGFXCFSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 147146   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM147146 (US8957077, 1-23) Show SMILES Cc1nc(C)c(CNc2cc(nc3ccnn23)C(=O)NC[C@H]2C[C@@H]2c2ccc3ccccc3n2)s1 |r| Show InChI InChI=1S/C26H25N7OS/c1-15-23(35-16(2)30-15)14-27-25-12-22(32-24-9-10-29-33(24)25)26(34)28-13-18-11-19(18)21-8-7-17-5-3-4-6-20(17)31-21/h3-10,12,18-19,27H,11,13-14H2,1-2H3,(H,28,34)/t18-,19+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exper...				US Patent US8957077 (2015) BindingDB Entry DOI: 10.7270/Q29G5KHW
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