BDBM147152 US8957083, 29

SMILES: COc1ccc2Oc3c(F)cc(cc3[C@@]3(N=C(N)N(C)C3=O)c2c1)-c1ccc(C)cc1

InChI Key: InChIKey=XPSVCWWCFKBVGW-DEOSSOPVSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 147152   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 1 (Homo sapiens (Human))	BDBM147152 (US8957083, 29) Show SMILES COc1ccc2Oc3c(F)cc(cc3[C@@]3(N=C(N)N(C)C3=O)c2c1)-c1ccc(C)cc1 |r,t:16| Show InChI InChI=1S/C24H20FN3O3/c1-13-4-6-14(7-5-13)15-10-18-21(19(25)11-15)31-20-9-8-16(30-3)12-17(20)24(18)22(29)28(2)23(26)27-24/h4-12H,1-3H3,(H2,26,27)/t24-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13.6	n/a	n/a	n/a	n/a	4.2	n/a
Amgen Inc. US Patent					Assay Description The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...				US Patent US8957083 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TS5
					More data for this Ligand-Target Pair