BDBM147176 US8957083, 14

SMILES: CN1C(=O)C[C@@]2(N=C1N)c1cc(ccc1Oc1c(F)nc(Cl)cc21)-c1cccnc1F

InChI Key: InChIKey=DEPCYHWMXVFRSU-OAQYLSRUSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 147176   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Beta-secretase 1 (Homo sapiens (Human))	BDBM147176 (US8957083, 14) Show SMILES CN1C(=O)C[C@@]2(N=C1N)c1cc(ccc1Oc1c(F)nc(Cl)cc21)-c1cccnc1F |r,c:6| Show InChI InChI=1S/C21H14ClF2N5O2/c1-29-16(30)9-21(28-20(29)25)12-7-10(11-3-2-6-26-18(11)23)4-5-14(12)31-17-13(21)8-15(22)27-19(17)24/h2-8H,9H2,1H3,(H2,25,28)/t21-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.21E+3	n/a	n/a	n/a	n/a	4.2	n/a
Amgen Inc. US Patent					Assay Description The assay buffer used in this screen is 0.05 M acetate, pH 4.2, 10% DMSO final, 100 uM genapol (which is a nonionic detergent, below its Critical Mic...				US Patent US8957083 (2015) BindingDB Entry DOI: 10.7270/Q25Q4TS5
					More data for this Ligand-Target Pair