BDBM147188 US8957084, 1
SMILES: COc1ccc2C[C@@H]3C4C5CC5C(=O)C[C@]4(CCN3CC3CC3)c2c1
InChI Key: InChIKey=QOSLLECBPOIMAL-QZWDIJTMSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Kappa-type opioid receptor (Homo sapiens (Human)) | BDBM147188 (US8957084, 1) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 8.87 | -11.0 | n/a | n/a | n/a | n/a | n/a | 7.4 | 25 |
Purdue Pharma L.P. US Patent | Assay Description Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 ug membrane protein (recombinant... | US Patent US8957084 (2015) BindingDB Entry DOI: 10.7270/Q21Z433P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM147188 (US8957084, 1) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 112 | -10.3 | n/a | n/a | n/a | n/a | n/a | 7.4 | 50 |
Purdue Pharma L.P. US Patent | Assay Description Radioligand dose-displacement binding assays for u-opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membrane... | US Patent US8957084 (2015) BindingDB Entry DOI: 10.7270/Q21Z433P | |||||||||||
More data for this Ligand-Target Pair |