BDBM14740 (R)-6,7-Dimethoxy-4-(3-o-tolyloxy-pyrrolidin-1-yl)-quinazoline::6,7-Dimethoxy-4-pyrrolidylquinazoline 3::6,7-dimethoxy-4-[(3R)-3-(2-methylphenoxy)pyrrolidin-1-yl]quinazoline
SMILES: COc1cc2ncnc(N3CC[C@H](C3)Oc3ccccc3C)c2cc1OC
InChI Key: InChIKey=MUHUODHRRSHCNV-OAHLLOKOSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Phosphodiesterase 3 (PDE3) (Homo sapiens (Human)) | BDBM14740 ((R)-6,7-Dimethoxy-4-(3-o-tolyloxy-pyrrolidin-1-yl)...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | <100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by... | J Med Chem 50: 182-5 (2007) Article DOI: 10.1021/jm060653b BindingDB Entry DOI: 10.7270/Q2930RDX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM14740 ((R)-6,7-Dimethoxy-4-(3-o-tolyloxy-pyrrolidin-1-yl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 326 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
St. John's University Curated by ChEMBL | Assay Description Inhibition of PDE10A | Bioorg Med Chem 16: 3675-86 (2008) Article DOI: 10.1016/j.bmc.2008.02.013 BindingDB Entry DOI: 10.7270/Q2V988ZC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 10 (PDE10A) (Rattus norvegicus (rat)) | BDBM14740 ((R)-6,7-Dimethoxy-4-(3-o-tolyloxy-pyrrolidin-1-yl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 326 | -8.75 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Pfizer | Assay Description PDE activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using a scintillation proximity assay (SPA). [3H]-AMP was captured by... | J Med Chem 50: 182-5 (2007) Article DOI: 10.1021/jm060653b BindingDB Entry DOI: 10.7270/Q2930RDX | |||||||||||
More data for this Ligand-Target Pair |