BDBM147692 US10112907, Example 00025::US8962608, 28-1
SMILES: NC(=O)c1cn(nc1Nc1ccc(cc1)C(F)(F)F)[C@H]1CC[C@@H](C[C@@H]1[N+]#[C-])N1CCC1
InChI Key: InChIKey=YOHZCNFQWQKCFW-SZMVWBNQSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM147692 (US10112907, Example 00025 | US8962608, 28-1) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ... | US Patent US8962608 (2015) BindingDB Entry DOI: 10.7270/Q2J101W0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM147692 (US10112907, Example 00025 | US8962608, 28-1) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Sharp & Dohme Corp. US Patent | Assay Description The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ... | US Patent US8962608 (2015) BindingDB Entry DOI: 10.7270/Q2J101W0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
TYK2 (aa 888-1187) (Homo sapiens (Human)) | BDBM147692 (US10112907, Example 00025 | US8962608, 28-1) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
NOVARTIS AG US Patent | Assay Description A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J... | US Patent US10112907 (2018) BindingDB Entry DOI: 10.7270/Q2FX7CHW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
JAK2 (aa 808-1132) (Homo sapiens (Human)) | BDBM147692 (US10112907, Example 00025 | US8962608, 28-1) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
NOVARTIS AG US Patent | Assay Description A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J... | US Patent US10112907 (2018) BindingDB Entry DOI: 10.7270/Q2FX7CHW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
JAK3 (aa 811-1124) (Homo sapiens (Human)) | BDBM147692 (US10112907, Example 00025 | US8962608, 28-1) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
NOVARTIS AG US Patent | Assay Description A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J... | US Patent US10112907 (2018) BindingDB Entry DOI: 10.7270/Q2FX7CHW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
JAK1 (aa 866-1154) (Homo sapiens (Human)) | BDBM147692 (US10112907, Example 00025 | US8962608, 28-1) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 40 | n/a | n/a | n/a | n/a | 7.5 | n/a |
NOVARTIS AG US Patent | Assay Description A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J... | US Patent US10112907 (2018) BindingDB Entry DOI: 10.7270/Q2FX7CHW | |||||||||||
More data for this Ligand-Target Pair |