BDBM14824 4-({5-bromo-4-[(4-methoxyphenyl)amino]pyrimidin-2-yl}amino)benzoic acid::AstraZeneca compound 1::JMC514672 Compound 30

SMILES: COc1ccc(Nc2nc(Nc3ccc(cc3)C(O)=O)ncc2Br)cc1

InChI Key: InChIKey=YMPWYIHAVYUJEK-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 14824   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
BDNF/NT-3 growth factors receptor (Homo sapiens (Human))	BDBM14824 (4-({5-bromo-4-[(4-methoxyphenyl)amino]pyrimidin-2-...) Show SMILES COc1ccc(Nc2nc(Nc3ccc(cc3)C(O)=O)ncc2Br)cc1 Show InChI InChI=1S/C18H15BrN4O3/c1-26-14-8-6-12(7-9-14)21-16-15(19)10-20-18(23-16)22-13-4-2-11(3-5-13)17(24)25/h2-10H,1H3,(H,24,25)(H2,20,21,22,23)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	646	n/a	n/a	n/a	n/a	7.4	22
AstraZeneca					Assay Description TrkB kinase activity was measured against its ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substrate using homog...				J Med Chem 51: 4672-84 (2008) Article DOI: 10.1021/jm800343j BindingDB Entry DOI: 10.7270/Q2RN365V
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human))	BDBM14824 (4-({5-bromo-4-[(4-methoxyphenyl)amino]pyrimidin-2-...) Show SMILES COc1ccc(Nc2nc(Nc3ccc(cc3)C(O)=O)ncc2Br)cc1 Show InChI InChI=1S/C18H15BrN4O3/c1-26-14-8-6-12(7-9-14)21-16-15(19)10-20-18(23-16)22-13-4-2-11(3-5-13)17(24)25/h2-10H,1H3,(H,24,25)(H2,20,21,22,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	450	n/a	n/a	n/a	n/a	7.5	22
AstraZeneca					Assay Description The compound inhibitory activity was determined by incubation with purified recombinant Chk1 and biotinylated peptide substrate in the presence ATP/[...				J Med Chem 47: 1962-8 (2004) Article DOI: 10.1021/jm030504i BindingDB Entry DOI: 10.7270/Q2NC5ZFM
					More data for this Ligand-Target Pair