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SMILES: C[C@H]1CNC[C@@H](C)N1c1ccc(cn1)-c1cnc2c(cnn2c1)-c1cccc2ncccc12

InChI Key: InChIKey=UOBWTNVFBCTTAN-HDICACEKSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 148375   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human))	BDBM148375 (US10017516, Compound 34 | US9682983, 34) Show SMILES C[C@H]1CNC[C@@H](C)N1c1ccc(cn1)-c1cnc2c(cnn2c1)-c1cccc2ncccc12 |r| Show InChI InChI=1S/C26H25N7/c1-17-11-27-12-18(2)33(17)25-9-8-19(13-29-25)20-14-30-26-23(15-31-32(26)16-20)21-5-3-7-24-22(21)6-4-10-28-24/h3-10,13-18,27H,11-12H2,1-2H3/t17-,18+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	189	n/a	n/a	n/a	n/a	7.5	n/a
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent					Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2...				US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R
					More data for this Ligand-Target Pair
Activin receptor type-1 (Homo sapiens (Human))	BDBM148375 (US10017516, Compound 34 | US9682983, 34) Show SMILES C[C@H]1CNC[C@@H](C)N1c1ccc(cn1)-c1cnc2c(cnn2c1)-c1cccc2ncccc12 |r| Show InChI InChI=1S/C26H25N7/c1-17-11-27-12-18(2)33(17)25-9-8-19(13-29-25)20-14-30-26-23(15-31-32(26)16-20)21-5-3-7-24-22(21)6-4-10-28-24/h3-10,13-18,27H,11-12H2,1-2H3/t17-,18+	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	56	n/a	n/a	n/a	n/a	7.5	n/a
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent					Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2...				US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A (Homo sapiens (Human))	BDBM148375 (US10017516, Compound 34 | US9682983, 34) Show SMILES C[C@H]1CNC[C@@H](C)N1c1ccc(cn1)-c1cnc2c(cnn2c1)-c1cccc2ncccc12 |r| Show InChI InChI=1S/C26H25N7/c1-17-11-27-12-18(2)33(17)25-9-8-19(13-29-25)20-14-30-26-23(15-31-32(26)16-20)21-5-3-7-24-22(21)6-4-10-28-24/h3-10,13-18,27H,11-12H2,1-2H3/t17-,18+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.28E+3	n/a	n/a	n/a	n/a	7.5	n/a
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent					Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2...				US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R
					More data for this Ligand-Target Pair
Activin receptor type-1B (Homo sapiens (Human))	BDBM148375 (US10017516, Compound 34 | US9682983, 34) Show SMILES C[C@H]1CNC[C@@H](C)N1c1ccc(cn1)-c1cnc2c(cnn2c1)-c1cccc2ncccc12 |r| Show InChI InChI=1S/C26H25N7/c1-17-11-27-12-18(2)33(17)25-9-8-19(13-29-25)20-14-30-26-23(15-31-32(26)16-20)21-5-3-7-24-22(21)6-4-10-28-24/h3-10,13-18,27H,11-12H2,1-2H3/t17-,18+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.08E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Brigham and Women's Hospital, Inc. US Patent					Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ...				US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase receptor R3 (Homo sapiens (Human))	BDBM148375 (US10017516, Compound 34 | US9682983, 34) Show SMILES C[C@H]1CNC[C@@H](C)N1c1ccc(cn1)-c1cnc2c(cnn2c1)-c1cccc2ncccc12 |r| Show InChI InChI=1S/C26H25N7/c1-17-11-27-12-18(2)33(17)25-9-8-19(13-29-25)20-14-30-26-23(15-31-32(26)16-20)21-5-3-7-24-22(21)6-4-10-28-24/h3-10,13-18,27H,11-12H2,1-2H3/t17-,18+	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	189	n/a	n/a	n/a	n/a	n/a	n/a
The Brigham and Women's Hospital, Inc. US Patent					Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ...				US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN
					More data for this Ligand-Target Pair
Activin receptor type-1 (Homo sapiens (Human))	BDBM148375 (US10017516, Compound 34 | US9682983, 34) Show SMILES C[C@H]1CNC[C@@H](C)N1c1ccc(cn1)-c1cnc2c(cnn2c1)-c1cccc2ncccc12 |r| Show InChI InChI=1S/C26H25N7/c1-17-11-27-12-18(2)33(17)25-9-8-19(13-29-25)20-14-30-26-23(15-31-32(26)16-20)21-5-3-7-24-22(21)6-4-10-28-24/h3-10,13-18,27H,11-12H2,1-2H3/t17-,18+	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
The Brigham and Women's Hospital, Inc. US Patent					Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ...				US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN
					More data for this Ligand-Target Pair
Bone morphogenetic protein receptor type-1A (Homo sapiens (Human))	BDBM148375 (US10017516, Compound 34 | US9682983, 34) Show SMILES C[C@H]1CNC[C@@H](C)N1c1ccc(cn1)-c1cnc2c(cnn2c1)-c1cccc2ncccc12 |r| Show InChI InChI=1S/C26H25N7/c1-17-11-27-12-18(2)33(17)25-9-8-19(13-29-25)20-14-30-26-23(15-31-32(26)16-20)21-5-3-7-24-22(21)6-4-10-28-24/h3-10,13-18,27H,11-12H2,1-2H3/t17-,18+	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.28E+3	n/a	n/a	n/a	n/a	n/a	n/a
The Brigham and Women's Hospital, Inc. US Patent					Assay Description Compounds were assessed in ALK1-6 enzymatic assays. Specifically, compounds were assayed using LANCE® Ultra ULight technology (Perkin Elmer) against ...				US Patent US10017516 (2018) BindingDB Entry DOI: 10.7270/Q20P12CN
					More data for this Ligand-Target Pair
Activin receptor type-1B (Homo sapiens (Human))	BDBM148375 (US10017516, Compound 34 | US9682983, 34) Show SMILES C[C@H]1CNC[C@@H](C)N1c1ccc(cn1)-c1cnc2c(cnn2c1)-c1cccc2ncccc12 |r| Show InChI InChI=1S/C26H25N7/c1-17-11-27-12-18(2)33(17)25-9-8-19(13-29-25)20-14-30-26-23(15-31-32(26)16-20)21-5-3-7-24-22(21)6-4-10-28-24/h3-10,13-18,27H,11-12H2,1-2H3/t17-,18+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.08E+3	n/a	n/a	n/a	n/a	7.5	n/a
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent					Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2...				US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R
					More data for this Ligand-Target Pair