null

SMILES: CN1CCn2nc(Nc3cc(n[nH]c3=O)-c3cccc(N4Cc5cc(sc5C4=O)C(C)(C)C)c3C)cc2C1

InChI Key: InChIKey=ADIGCBHSQFHVRD-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 149463   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM149463 (US8975260, 101) Show SMILES CN1CCn2nc(Nc3cc(n[nH]c3=O)-c3cccc(N4Cc5cc(sc5C4=O)C(C)(C)C)c3C)cc2C1 Show InChI InChI=1S/C28H31N7O2S/c1-16-19(7-6-8-22(16)34-14-17-11-23(28(2,3)4)38-25(17)27(34)37)20-13-21(26(36)31-30-20)29-24-12-18-15-33(5)9-10-35(18)32-24/h6-8,11-13H,9-10,14-15H2,1-5H3,(H,31,36)(H,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	7.5	n/a
Genetech, Inc; Gilead Connecticut, Inc. US Patent					Assay Description A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus Bt...				US Patent US8975260 (2015) BindingDB Entry DOI: 10.7270/Q2PK0DW9
					More data for this Ligand-Target Pair