BDBM149466 US8975260, 113

SMILES: Cc1c(cccc1-c1cc(Nc2cc([nH]n2)C2CC2)c(=O)[nH]n1)N1Cc2cc(sc2C1=O)C(C)(C)C

InChI Key: InChIKey=YGKZJAKJFAGODW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 149466   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM149466 (US8975260, 113) Show SMILES Cc1c(cccc1-c1cc(Nc2cc([nH]n2)C2CC2)c(=O)[nH]n1)N1Cc2cc(sc2C1=O)C(C)(C)C Show InChI InChI=1S/C27H28N6O2S/c1-14-17(19-11-20(25(34)32-30-19)28-23-12-18(29-31-23)15-8-9-15)6-5-7-21(14)33-13-16-10-22(27(2,3)4)36-24(16)26(33)35/h5-7,10-12,15H,8-9,13H2,1-4H3,(H,32,34)(H2,28,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.5	n/a
Genetech, Inc; Gilead Connecticut, Inc. US Patent					Assay Description A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus Bt...				US Patent US8975260 (2015) BindingDB Entry DOI: 10.7270/Q2PK0DW9
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