BDBM149467 US8975260, 114

SMILES: Cc1cc(Nc2cc(n[nH]c2=O)-c2ccc(F)c(c2)N2Cc3cc(sc3C2=O)C(C)(C)C)nn1C

InChI Key: InChIKey=XDOHTJZKHHRFGR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 149467   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM149467 (US8975260, 114) Show SMILES Cc1cc(Nc2cc(n[nH]c2=O)-c2ccc(F)c(c2)N2Cc3cc(sc3C2=O)C(C)(C)C)nn1C Show InChI InChI=1S/C25H25FN6O2S/c1-13-8-21(30-31(13)5)27-18-11-17(28-29-23(18)33)14-6-7-16(26)19(9-14)32-12-15-10-20(25(2,3)4)35-22(15)24(32)34/h6-11H,12H2,1-5H3,(H,29,33)(H,27,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	7.5	n/a
Genetech, Inc; Gilead Connecticut, Inc. US Patent					Assay Description A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus Bt...				US Patent US8975260 (2015) BindingDB Entry DOI: 10.7270/Q2PK0DW9
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