null

SMILES: CN1CCn2nc(Nc3cc(nn(C)c3=O)-c3cccc(N4Cc5cc(sc5C4=O)C(C)(C)C)c3CO)cc2C1

InChI Key: InChIKey=VZDDUZAFBGBYFG-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 149473   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM149473 (US8975260, 120) Show SMILES CN1CCn2nc(Nc3cc(nn(C)c3=O)-c3cccc(N4Cc5cc(sc5C4=O)C(C)(C)C)c3CO)cc2C1 Show InChI InChI=1S/C29H33N7O3S/c1-29(2,3)24-11-17-14-35(28(39)26(17)40-24)23-8-6-7-19(20(23)16-37)21-13-22(27(38)34(5)31-21)30-25-12-18-15-33(4)9-10-36(18)32-25/h6-8,11-13,37H,9-10,14-16H2,1-5H3,(H,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	7.5	n/a
Genetech, Inc; Gilead Connecticut, Inc. US Patent					Assay Description A generalized procedure for a standard biochemical Btk Kinase Assay that can be used to test Formula I compounds is as follows. A master mix minus Bt...				US Patent US8975260 (2015) BindingDB Entry DOI: 10.7270/Q2PK0DW9
					More data for this Ligand-Target Pair