BDBM14957 5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(2-((3-(dimethylamino)propyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-2-fluorobenzamide::5-[2-(2-aminopyrimidin-5-yl)ethynyl]-N-(2-{[3-(dimethylamino)propyl](methyl)amino}-5-(trifluoromethyl)phenyl)-2-fluorobenzamide::alkynylpyrimidine amide 6h

SMILES: CN(C)CCCN(C)c1ccc(cc1NC(=O)c1cc(ccc1F)C#Cc1cnc(N)nc1)C(F)(F)F

InChI Key: InChIKey=CPTZKLNMWGFJMW-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 14957   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM14957 (5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(2-((3-(dim...) Show SMILES CN(C)CCCN(C)c1ccc(cc1NC(=O)c1cc(ccc1F)C#Cc1cnc(N)nc1)C(F)(F)F Show InChI InChI=1S/C26H26F4N6O/c1-35(2)11-4-12-36(3)23-10-8-19(26(28,29)30)14-22(23)34-24(37)20-13-17(7-9-21(20)27)5-6-18-15-32-25(31)33-16-18/h7-10,13-16H,4,11-12H2,1-3H3,(H,34,37)(H2,31,32,33)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 50: 627-40 (2007) Article DOI: 10.1021/jm061112p BindingDB Entry DOI: 10.7270/Q2R49P1Z
					More data for this Ligand-Target Pair
Lck (Homo sapiens (Human))	BDBM14957 (5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(2-((3-(dim...) Show SMILES CN(C)CCCN(C)c1ccc(cc1NC(=O)c1cc(ccc1F)C#Cc1cnc(N)nc1)C(F)(F)F Show InChI InChI=1S/C26H26F4N6O/c1-35(2)11-4-12-36(3)23-10-8-19(26(28,29)30)14-22(23)34-24(37)20-13-17(7-9-21(20)27)5-6-18-15-32-25(31)33-16-18/h7-10,13-16H,4,11-12H2,1-3H3,(H,34,37)(H2,31,32,33)	PDB MMDB B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 50: 627-40 (2007) Article DOI: 10.1021/jm061112p BindingDB Entry DOI: 10.7270/Q2R49P1Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM14957 (5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(2-((3-(dim...) Show SMILES CN(C)CCCN(C)c1ccc(cc1NC(=O)c1cc(ccc1F)C#Cc1cnc(N)nc1)C(F)(F)F Show InChI InChI=1S/C26H26F4N6O/c1-35(2)11-4-12-36(3)23-10-8-19(26(28,29)30)14-22(23)34-24(37)20-13-17(7-9-21(20)27)5-6-18-15-32-25(31)33-16-18/h7-10,13-16H,4,11-12H2,1-3H3,(H,34,37)(H2,31,32,33)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 50: 627-40 (2007) Article DOI: 10.1021/jm061112p BindingDB Entry DOI: 10.7270/Q2R49P1Z
					More data for this Ligand-Target Pair