BDBM14961 (S)-5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(2-(3-(dimethylamino)piperidin-1-yl)-5-(trifluoromethyl)phenyl)-2-fluorobenzamide::5-[2-(2-aminopyrimidin-5-yl)ethynyl]-N-{2-[(3S)-3-(dimethylamino)piperidin-1-yl]-5-(trifluoromethyl)phenyl}-2-fluorobenzamide::alkynylpyrimidine amide 6l

SMILES: CN(C)[C@H]1CCCN(C1)c1ccc(cc1NC(=O)c1cc(ccc1F)C#Cc1cnc(N)nc1)C(F)(F)F

InChI Key: InChIKey=GMVQPWCWWLPOQT-FQEVSTJZSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 14961   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Angiopoietin-1 receptor (Homo sapiens (Human))	BDBM14961 ((S)-5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(2-(3-(...) Show SMILES CN(C)[C@H]1CCCN(C1)c1ccc(cc1NC(=O)c1cc(ccc1F)C#Cc1cnc(N)nc1)C(F)(F)F |r| Show InChI InChI=1S/C27H26F4N6O/c1-36(2)20-4-3-11-37(16-20)24-10-8-19(27(29,30)31)13-23(24)35-25(38)21-12-17(7-9-22(21)28)5-6-18-14-33-26(32)34-15-18/h7-10,12-15,20H,3-4,11,16H2,1-2H3,(H,35,38)(H2,32,33,34)/t20-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	7.5	22
Amgen					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 50: 627-40 (2007) Article DOI: 10.1021/jm061112p BindingDB Entry DOI: 10.7270/Q2R49P1Z
					More data for this Ligand-Target Pair
Lck (Homo sapiens (Human))	BDBM14961 ((S)-5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(2-(3-(...) Show SMILES CN(C)[C@H]1CCCN(C1)c1ccc(cc1NC(=O)c1cc(ccc1F)C#Cc1cnc(N)nc1)C(F)(F)F |r| Show InChI InChI=1S/C27H26F4N6O/c1-36(2)20-4-3-11-37(16-20)24-10-8-19(27(29,30)31)13-23(24)35-25(38)21-12-17(7-9-22(21)28)5-6-18-14-33-26(32)34-15-18/h7-10,12-15,20H,3-4,11,16H2,1-2H3,(H,35,38)(H2,32,33,34)/t20-/m0/s1	PDB MMDB B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 50: 627-40 (2007) Article DOI: 10.1021/jm061112p BindingDB Entry DOI: 10.7270/Q2R49P1Z
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM14961 ((S)-5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(2-(3-(...) Show SMILES CN(C)[C@H]1CCCN(C1)c1ccc(cc1NC(=O)c1cc(ccc1F)C#Cc1cnc(N)nc1)C(F)(F)F |r| Show InChI InChI=1S/C27H26F4N6O/c1-36(2)20-4-3-11-37(16-20)24-10-8-19(27(29,30)31)13-23(24)35-25(38)21-12-17(7-9-22(21)28)5-6-18-14-33-26(32)34-15-18/h7-10,12-15,20H,3-4,11,16H2,1-2H3,(H,35,38)(H2,32,33,34)/t20-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.03E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...				J Med Chem 50: 627-40 (2007) Article DOI: 10.1021/jm061112p BindingDB Entry DOI: 10.7270/Q2R49P1Z
					More data for this Ligand-Target Pair