null

SMILES: COC(=O)c1cc2C[C@@]3(O)[C@H]4Cc5ccc(OC)cc5[C@@]3(CCN4Cc3ccccc3)Cc2[nH]c1=O

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 150228   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM150228 (US8980906, 30) Show SMILES COC(=O)c1cc2C[C@@]3(O)[C@H]4Cc5ccc(OC)cc5[C@@]3(CCN4Cc3ccccc3)Cc2[nH]c1=O |r,TLB:9:8:19.12.11:23.21.22,7:8:19.12.11:23.21.22| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	599	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Purdue Pharma L.P. US Patent					Assay Description Radioligand dose displacement assays used 0.4 nM [3H]-U69,593 (GE Healthcare, Piscataway, N.J.; 40 Ci/mmole) with 15 μg membrane protein (recomb...				US Patent US8980906 (2015) BindingDB Entry DOI: 10.7270/Q2W37V15
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM150228 (US8980906, 30) Show SMILES COC(=O)c1cc2C[C@@]3(O)[C@H]4Cc5ccc(OC)cc5[C@@]3(CCN4Cc3ccccc3)Cc2[nH]c1=O |r,TLB:9:8:19.12.11:23.21.22,7:8:19.12.11:23.21.22| Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	3.94E+3	-7.99	n/a	n/a	n/a	n/a	n/a	7.4	50
Purdue Pharma L.P. US Patent					Assay Description Radioligand dose-displacement binding assays for mu-opioid receptors used 0.3 nM [3H]-diprenorphine (Perkin Elmer, Shelton, Conn.), with 5 mg membran...				US Patent US8980906 (2015) BindingDB Entry DOI: 10.7270/Q2W37V15
					More data for this Ligand-Target Pair