BDBM15028 5-[(2S)-2-amino-3-phenylpropoxy]-N-(pyridin-3-ylmethyl)pyridin-3-amine::pyridine-base inhibitor 5b

SMILES: N[C@H](COc1cncc(NCc2cccnc2)c1)Cc1ccccc1

InChI Key: InChIKey=XIYKNFHYHHMJEM-SFHVURJKSA-N

Data: 1 Other

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 15028   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15028 (5-[(2S)-2-amino-3-phenylpropoxy]-N-(pyridin-3-ylme...) Show SMILES N[C@H](COc1cncc(NCc2cccnc2)c1)Cc1ccccc1 |r| Show InChI InChI=1S/C20H22N4O/c21-18(9-16-5-2-1-3-6-16)15-25-20-10-19(13-23-14-20)24-12-17-7-4-8-22-11-17/h1-8,10-11,13-14,18,24H,9,12,15,21H2/t18-/m0/s1	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair