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BDBM150286 US8987242, 62

SMILES: Cc1ccc(cc1)N1CCO[C@H]([C@@H](O)C(=O)Nc2ccc3c(N)nccc3c2)C1=O

InChI Key: InChIKey=DVFFOPCTIUMLFN-RTBURBONSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 150286   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Coagulation factor IX


(Homo sapiens (Human))		BDBM150286
PNG
(US8987242, 62)
Show SMILES Cc1ccc(cc1)N1CCO[C@H]([C@@H](O)C(=O)Nc2ccc3c(N)nccc3c2)C1=O |r|
Show InChI InChI=1S/C22H22N4O4/c1-13-2-5-16(6-3-13)26-10-11-30-19(22(26)29)18(27)21(28)25-15-4-7-17-14(12-15)8-9-24-20(17)23/h2-9,12,18-19,27H,10-11H2,1H3,(H2,23,24)(H,25,28)/t18-,19-/m1/s1
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Similars
US Patent
n/an/a 20n/an/an/an/a8.025



Merck Sharp & Dohme Corp.; Mochida Pharmaceuticals Co., Ltd.

US Patent


Assay Description
Inhibitory activity against factor IXa was tested using the substrate SPECTROFLUOR FIXa (american diagnostica inc.; 500 West Avenue, Stamford, Conn. ...

US Patent US8987242 (2015)


BindingDB Entry DOI: 10.7270/Q2ZW1JNS
More data for this
Ligand-Target Pair