BDBM15053 N-(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl}phenyl)methanesulfonamide::pyridine-base inhibitor 9p

SMILES: CS(=O)(=O)Nc1ccc(cc1)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1

InChI Key: InChIKey=WNXJSXBPKJWPJT-IBGZPJMESA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 15053   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15053 (N-(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyr...) Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1 |r| Show InChI InChI=1S/C23H24N4O3S/c1-31(28,29)27-20-8-6-16(7-9-20)17-11-21(14-25-12-17)30-15-19(24)10-18-13-26-23-5-3-2-4-22(18)23/h2-9,11-14,19,26-27H,10,15,24H2,1H3/t19-/m0/s1	PDB MMDB B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair