BDBM150774 3-(2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)acetyl)-2H-chromen-2-one (7)

SMILES: O=C(CSc1nnc2c(n1)[nH]c1ccccc21)c1cc2ccccc2oc1=O

InChI Key: InChIKey=YRUAQVQXXQOXBE-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 150774   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
α-glucosidase (Saccharomyces cerevisiae S288c (Baker's yeast))	BDBM150774 (3-(2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)acet...) Show SMILES O=C(CSc1nnc2c(n1)[nH]c1ccccc21)c1cc2ccccc2oc1=O Show InChI InChI=1S/C20H12N4O3S/c25-15(13-9-11-5-1-4-8-16(11)27-19(13)26)10-28-20-22-18-17(23-24-20)12-6-2-3-7-14(12)21-18/h1-9H,10H2,(H,21,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.74E+4	n/a	n/a	n/a	n/a	n/a	310.15
Hazara University					Assay Description Typically, α-glucosidase activity was assayed in 50 mM phosphate buffer (pH 6.8) containing 5% v/v DMSO and PNP glycoside was used as a substrat...				Bioorg Chem 58: 81-7 (2015) Article DOI: 10.1016/j.bioorg.2014.12.001 BindingDB Entry DOI: 10.7270/Q2JQ0ZR8
					More data for this Ligand-Target Pair