BDBM150855 US8981106, 44

SMILES: Cc1cc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)no1

InChI Key: InChIKey=MLFYDRDYIAWWHT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 150855   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM150855 (US8981106, 44) Show SMILES Cc1cc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)no1 Show InChI InChI=1S/C17H14FN3O2S/c1-11-8-15(21-23-11)10-24-16-7-2-12(9-19-16)17(22)20-14-5-3-13(18)4-6-14/h2-9H,10H2,1H3,(H,20,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Syntrix Biosystems Curated by ChEMBL					Assay Description Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...				J Med Chem 57: 8378-97 (2014) Article DOI: 10.1021/jm500827t BindingDB Entry DOI: 10.7270/Q2FX7C22
					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM150855 (US8981106, 44) Show SMILES Cc1cc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)no1 Show InChI InChI=1S/C17H14FN3O2S/c1-11-8-15(21-23-11)10-24-16-7-2-12(9-19-16)17(22)20-14-5-3-13(18)4-6-14/h2-9H,10H2,1H3,(H,20,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>5.00E+3	n/a	n/a	n/a	n/a	n/a	37
Syntrix Biosystems, Inc. US Patent					Assay Description An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+...				US Patent US8981106 (2015) BindingDB Entry DOI: 10.7270/Q2WW7GC1
					More data for this Ligand-Target Pair