BDBM150968 US8981106, 158::USRE47267, Compound 158
SMILES: OB(O)c1ccccc1CSc1ccc(cn1)C(=O)N(CC(O)=O)c1ccc(F)cc1
InChI Key: InChIKey=YDYSHHNSZKNUQE-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM150968 (US8981106, 158 | USRE47267, Compound 158) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.99E+3 | n/a | n/a | n/a | n/a | n/a | 37 |
Syntrix Biosystems, Inc. US Patent | Assay Description An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+... | US Patent US8981106 (2015) BindingDB Entry DOI: 10.7270/Q2WW7GC1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM150968 (US8981106, 158 | USRE47267, Compound 158) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.99E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntrix Biosystems, Inc. US Patent | Assay Description The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium... | US Patent USRE47267 (2019) BindingDB Entry DOI: 10.7270/Q2GF0WSH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM150968 (US8981106, 158 | USRE47267, Compound 158) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.99E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntrix Biosystems Curated by ChEMBL | Assay Description Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa... | J Med Chem 57: 8378-97 (2014) Article DOI: 10.1021/jm500827t BindingDB Entry DOI: 10.7270/Q2FX7C22 | |||||||||||
More data for this Ligand-Target Pair |