null

SMILES: C[C@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cccc2[nH]ccc12)N1CCC(O)CC1

InChI Key: InChIKey=JFQQDYBSDHBVEK-UXPDKRSESA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 151003   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM151003 (US8987257, 16) Show SMILES C[C@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cccc2[nH]ccc12)N1CCC(O)CC1 |r| Show InChI InChI=1S/C23H25N7O2/c1-14-13-32-12-11-30(14)22-19-21(27-23(28-22)29-9-6-15(31)7-10-29)26-20(25-19)17-3-2-4-18-16(17)5-8-24-18/h2-5,8,14-15,31H,6-7,9-13H2,1H3/b20-17-/t14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	160	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a...				US Patent US8987257 (2015) BindingDB Entry DOI: 10.7270/Q2S75F2B
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM151003 (US8987257, 16) Show SMILES C[C@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cccc2[nH]ccc12)N1CCC(O)CC1 |r| Show InChI InChI=1S/C23H25N7O2/c1-14-13-32-12-11-30(14)22-19-21(27-23(28-22)29-9-6-15(31)7-10-29)26-20(25-19)17-3-2-4-18-16(17)5-8-24-18/h2-5,8,14-15,31H,6-7,9-13H2,1H3/b20-17-/t14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.30E+3	n/a	n/a	n/a	n/a	7.5	4
Novartis AG US Patent					Assay Description PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS...				US Patent US8987257 (2015) BindingDB Entry DOI: 10.7270/Q2S75F2B
					More data for this Ligand-Target Pair