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SMILES: COC1CCN(CC1)c1nc(N2CCOCC2)c2nc([nH]c2n1)-c1cccc2[nH]ccc12

InChI Key: InChIKey=KRXHAQBOIOEJDX-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 151012   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM151012 (US8987257, 25) Show SMILES COC1CCN(CC1)c1nc(N2CCOCC2)c2nc([nH]c2n1)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C23H27N7O2/c1-31-15-6-9-30(10-7-15)23-27-21-19(22(28-23)29-11-13-32-14-12-29)25-20(26-21)17-3-2-4-18-16(17)5-8-24-18/h2-5,8,15,24H,6-7,9-14H2,1H3,(H,25,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	172	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a...				US Patent US8987257 (2015) BindingDB Entry DOI: 10.7270/Q2S75F2B
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM151012 (US8987257, 25) Show SMILES COC1CCN(CC1)c1nc(N2CCOCC2)c2nc([nH]c2n1)-c1cccc2[nH]ccc12 Show InChI InChI=1S/C23H27N7O2/c1-31-15-6-9-30(10-7-15)23-27-21-19(22(28-23)29-11-13-32-14-12-29)25-20(26-21)17-3-2-4-18-16(17)5-8-24-18/h2-5,8,15,24H,6-7,9-14H2,1H3,(H,25,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.07E+3	n/a	n/a	n/a	n/a	7.5	4
Novartis AG US Patent					Assay Description PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS...				US Patent US8987257 (2015) BindingDB Entry DOI: 10.7270/Q2S75F2B
					More data for this Ligand-Target Pair