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SMILES: OCc1cccc(c1)-c1nc2c(nc(nc2[nH]1)N1CCOCC1)N1CCOCC1

InChI Key: InChIKey=HHASSGIDQRQXQL-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 151024   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))		BDBM151024
PNG
(US8987257, 37)
Show SMILES OCc1cccc(c1)-c1nc2c(nc(nc2[nH]1)N1CCOCC1)N1CCOCC1
Show InChI InChI=1S/C20H24N6O3/c27-13-14-2-1-3-15(12-14)17-21-16-18(22-17)23-20(26-6-10-29-11-7-26)24-19(16)25-4-8-28-9-5-25/h1-3,12,27H,4-11,13H2,(H,21,22,23,24)
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Similars
US Patent
n/an/a 10n/an/an/an/a7.54



Novartis AG

US Patent


Assay Description
PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS...

US Patent US8987257 (2015)


BindingDB Entry DOI: 10.7270/Q2S75F2B
More data for this
Ligand-Target Pair