BDBM151037 US8987268, 51

SMILES: CCOC(=O)N1CCC[C@H](C1)Nc1c(cnn2cc(cc12)-c1ccccc1)C(N)=O

InChI Key: InChIKey=JJGOYTQCWBREEM-QGZVFWFLSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 151037   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM151037 (US8987268, 51) Show SMILES CCOC(=O)N1CCC[C@H](C1)Nc1c(cnn2cc(cc12)-c1ccccc1)C(N)=O Show InChI InChI=1S/C22H25N5O3/c1-2-30-22(29)26-10-6-9-17(14-26)25-20-18(21(23)28)12-24-27-13-16(11-19(20)27)15-7-4-3-5-8-15/h3-5,7-8,11-13,17,25H,2,6,9-10,14H2,1H3,(H2,23,28)/t17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	903	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The assay reactions were performed in U-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme and substrat...				US Patent US8987268 (2015) BindingDB Entry DOI: 10.7270/Q2NG4PC2
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK3 (Homo sapiens (Human))	BDBM151037 (US8987268, 51) Show SMILES CCOC(=O)N1CCC[C@H](C1)Nc1c(cnn2cc(cc12)-c1ccccc1)C(N)=O Show InChI InChI=1S/C22H25N5O3/c1-2-30-22(29)26-10-6-9-17(14-26)25-20-18(21(23)28)12-24-27-13-16(11-19(20)27)15-7-4-3-5-8-15/h3-5,7-8,11-13,17,25H,2,6,9-10,14H2,1H3,(H2,23,28)/t17-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	285	n/a	n/a	n/a	n/a	7.4	25
Bristol-Myers Squibb Company US Patent					Assay Description The assay reactions were performed in U-bottom 384-well plates. The final assay volume was 30 ul prepared from 15 ul additions of enzyme and substrat...				US Patent US8987268 (2015) BindingDB Entry DOI: 10.7270/Q2NG4PC2
					More data for this Ligand-Target Pair