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BDBM15107 3-[(2S)-2-amino-3-({4-[(E)-2-(pyridin-4-yl)ethenyl]pyridin-2-yl}oxy)propyl]-1H-indole::trans-bispyridinylethylene analog 6b

SMILES: N[C@H](COc1cc(\C=C\c2ccncc2)ccn1)Cc1c[nH]c2ccccc12

InChI Key: InChIKey=SCHRTFXRDSLPTA-XJDXJNMNSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 15107   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein kinase B (Akt 1)


(Homo sapiens (Human))		BDBM15107
PNG
(3-[(2S)-2-amino-3-({4-[(E)-2-(pyridin-4-yl)ethenyl...)
Show SMILES N[C@H](COc1cc(\C=C\c2ccncc2)ccn1)Cc1c[nH]c2ccccc12 |r|
Show InChI InChI=1S/C23H22N4O/c24-20(14-19-15-27-22-4-2-1-3-21(19)22)16-28-23-13-18(9-12-26-23)6-5-17-7-10-25-11-8-17/h1-13,15,20,27H,14,16,24H2/b6-5+/t20-/m0/s1
PDB
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...

Bioorg Med Chem Lett 16: 1679-85 (2006)


Article DOI: 10.1016/j.bmcl.2005.12.017
BindingDB Entry DOI: 10.7270/Q23F4MWN
More data for this
Ligand-Target Pair