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BDBM151274 US8987314, B70

SMILES: COCCS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc(NC(=O)OC(C)(C)C)cc1

InChI Key: InChIKey=CULATTJITQEPMN-UHFFFAOYNA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 151274   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatic Lipase (HL)


(Homo sapiens (Human))
BDBM151274
PNG
(US8987314, B70)
Show SMILES COCCS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc(NC(=O)OC(C)(C)C)cc1
Show InChI InChI=1/C25H32N4O8S3/c1-25(2,3)37-24(31)28-18-8-5-16(6-9-18)17-7-10-19-20(15-17)38-23(29-19)21(39(32,33)14-12-36-4)22(30)27-11-13-40(26,34)35/h5-10,15,21H,11-14H2,1-4H3,(H,27,30)(H,28,31)(H2,26,34,35)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM151274
PNG
(US8987314, B70)
Show SMILES COCCS(=O)(=O)C(C(=O)NCCS(N)(=O)=O)c1nc2ccc(cc2s1)-c1ccc(NC(=O)OC(C)(C)C)cc1
Show InChI InChI=1/C25H32N4O8S3/c1-25(2,3)37-24(31)28-18-8-5-16(6-9-18)17-7-10-19-20(15-17)38-23(29-19)21(39(32,33)14-12-36-4)22(30)27-11-13-40(26,34)35/h5-10,15,21H,11-14H2,1-4H3,(H,27,30)(H,28,31)(H2,26,34,35)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/a8.025



Bristol-Myers Squibb Company

US Patent


Assay Description
Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...


US Patent US8987314 (2015)


BindingDB Entry DOI: 10.7270/Q2W094N8
More data for this
Ligand-Target Pair