BDBM15195 Isoquinoline-5-sulfonic acid (2-(2-(2-chlorobenzyloxy)ethylamino)ethyl)amide::N-[2-({2-[(2-chlorophenyl)methoxy]ethyl}amino)ethyl]isoquinoline-5-sulfonamide::isoquinoline-5-sulfonamide 7
SMILES: Clc1ccccc1COCCNCCNS(=O)(=O)c1cccc2cnccc12
InChI Key: InChIKey=BYYJMPBGGOXCJZ-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP-Dependent Protein Kinase (PKA) (Bos taurus (bovine)) | BDBM15195 (Isoquinoline-5-sulfonic acid (2-(2-(2-chlorobenzyl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | 7.2 | 22 |
UK Centre for Cancer Therapeutics | Assay Description The recombinant alpha catalytic subunit of bovine PKA was assayed with a peptide substrate and test compound in the presence of 40 uM ATP/ [gamma-33P... | Bioorg Med Chem 14: 1255-73 (2006) Article DOI: 10.1016/j.bmc.2005.09.055 BindingDB Entry DOI: 10.7270/Q2FN14F2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human)) | BDBM15195 (Isoquinoline-5-sulfonic acid (2-(2-(2-chlorobenzyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 960 | n/a | n/a | n/a | n/a | 7.2 | 22 |
UK Centre for Cancer Therapeutics | Assay Description The purified PKB beta enzyme was assayed with a peptide substrate and test compound in the presence of 30 uM ATP/ [gamma-33P]ATP in 96-well plates. I... | Bioorg Med Chem 14: 1255-73 (2006) Article DOI: 10.1016/j.bmc.2005.09.055 BindingDB Entry DOI: 10.7270/Q2FN14F2 | |||||||||||
More data for this Ligand-Target Pair |