BDBM152931 US8993612, 5

SMILES: O=C(Cn1cnc2ccccc12)Nc1ccc(cc1)-n1nc(cc1C1CC1)C1CC1

InChI Key: InChIKey=MAJKGCYRUWETGW-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 152931   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM152931 (US8993612, 5) Show SMILES O=C(Cn1cnc2ccccc12)Nc1ccc(cc1)-n1nc(cc1C1CC1)C1CC1 Show InChI InChI=1S/C24H23N5O/c30-24(14-28-15-25-20-3-1-2-4-22(20)28)26-18-9-11-19(12-10-18)29-23(17-7-8-17)13-21(27-29)16-5-6-16/h1-4,9-13,15-17H,5-8,14H2,(H,26,30)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	383	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8993612 (2015) BindingDB Entry DOI: 10.7270/Q2CN72NK
					More data for this Ligand-Target Pair