BDBM152972 US8993614, 37

SMILES: COCCOCCOC(=O)OC(C)OC(=O)c1ccc(NC(=O)[C@@H]2N[C@@H](CC(C)(C)C)[C@@](C#N)([C@H]2c2cccc(Cl)c2F)c2ccc(Cl)cc2F)c(OC)c1

InChI Key: InChIKey=FIUSPLAVQUMADZ-WNCLNVGJSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 152972   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
E3 ubiquitin-protein ligase Mdm2 (Homo sapiens (Human))	BDBM152972 (US8993614, 37) Show SMILES COCCOCCOC(=O)OC(C)OC(=O)c1ccc(NC(=O)[C@@H]2N[C@@H](CC(C)(C)C)[C@@](C#N)([C@H]2c2cccc(Cl)c2F)c2ccc(Cl)cc2F)c(OC)c1 |r,Sg:n:3,2,4::ht| Show InChI InChI=1S/C39H43Cl2F2N3O9/c1-22(55-37(49)53-17-16-52-15-14-50-5)54-36(48)23-10-13-29(30(18-23)51-6)45-35(47)34-32(25-8-7-9-27(41)33(25)43)39(21-44,31(46-34)20-38(2,3)4)26-12-11-24(40)19-28(26)42/h7-13,18-19,22,31-32,34,46H,14-17,20H2,1-6H3,(H,45,47)/t22?,31-,32-,34+,39-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.14	n/a	n/a	n/a	n/a	n/a	n/a
F. Hoffmann-La Roche AG US Patent					Assay Description The ability of the compounds to inhibit the interaction between p53 and MDM2 proteins was measured by an HTRF (homogeneous time-resolved fluorescence...				US Patent US8993614 (2015) BindingDB Entry DOI: 10.7270/Q27W69XV
					More data for this Ligand-Target Pair