BDBM153385 2-(4,5-Dibromo-1H-pyrrole-2-carbonyl)-N-(4-nitrophenyl)hydrazine carbothioamide (5c)

SMILES: [O-][N+](=O)c1ccc(NC(=S)NNC(=O)c2cc(Br)c(Br)[nH]2)cc1

InChI Key: InChIKey=GWMXZICXDPPHIP-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 153385   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Macrophage metalloelastase (Homo sapiens (Human))	BDBM153385 (2-(4,5-Dibromo-1H-pyrrole-2-carbonyl)-N-(4-nitroph...) Show SMILES [O-][N+](=O)c1ccc(NC(=S)NNC(=O)c2cc(Br)c(Br)[nH]2)cc1 Show InChI InChI=1S/C12H9Br2N5O3S/c13-8-5-9(16-10(8)14)11(20)17-18-12(23)15-6-1-3-7(4-2-6)19(21)22/h1-5,16H,(H,17,20)(H2,15,18,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.21E+4	n/a	n/a	n/a	n/a	8.0	25
University of KwaZulu-Nata					Assay Description The synthesized compounds were assayed for the inhibitory activities against MMP-12 in 96-well microtiter plates using thiopeptolide as the substrate...				Chem Biol Drug Des 86: 210-22 (2015) Article DOI: 10.1111/cbdd.12481 BindingDB Entry DOI: 10.7270/Q2K64GSK
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM153385 (2-(4,5-Dibromo-1H-pyrrole-2-carbonyl)-N-(4-nitroph...) Show SMILES [O-][N+](=O)c1ccc(NC(=S)NNC(=O)c2cc(Br)c(Br)[nH]2)cc1 Show InChI InChI=1S/C12H9Br2N5O3S/c13-8-5-9(16-10(8)14)11(20)17-18-12(23)15-6-1-3-7(4-2-6)19(21)22/h1-5,16H,(H,17,20)(H2,15,18,23)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.37E+4	n/a	n/a	n/a	n/a	8.5	25
University of KwaZulu-Nata					Assay Description The synthesized compounds were assayed for the inhibitory activities against MMP-2 in 96-well microtiter plates using succinylated gelatin as the sub...				Chem Biol Drug Des 86: 210-22 (2015) Article DOI: 10.1111/cbdd.12481 BindingDB Entry DOI: 10.7270/Q2K64GSK
					More data for this Ligand-Target Pair