BDBM153392 4-(3-methoxyphenylamino)-8-methyl-6-(3-(methylcarbamoyl)phenylsulfonyl)quinoline-3-carboxamide (12b)

SMILES: CNC(=O)c1cccc(c1)S(=O)(=O)c1cc(C)c2ncc(C(N)=O)c(Nc3cccc(OC)c3)c2c1

InChI Key: InChIKey=HXOAJAXWRDRCMR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 153392   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Class I phosphodiesterase B1 (TbrPDEB1) (Trypanosoma brucei)	BDBM153392 (4-(3-methoxyphenylamino)-8-methyl-6-(3-(methylcarb...) Show SMILES CNC(=O)c1cccc(c1)S(=O)(=O)c1cc(C)c2ncc(C(N)=O)c(Nc3cccc(OC)c3)c2c1 Show InChI InChI=1S/C26H24N4O5S/c1-15-10-20(36(33,34)19-9-4-6-16(11-19)26(32)28-2)13-21-23(15)29-14-22(25(27)31)24(21)30-17-7-5-8-18(12-17)35-3/h4-14H,1-3H3,(H2,27,31)(H,28,32)(H,29,30)	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10E+4	n/a	n/a	n/a	n/a	7.4	n/a
Northeastern University					Assay Description In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25µM cAMP (Enzo Lifesci...				Chem Biol Drug Des 85: 549-64 (2015) Article DOI: 10.1111/cbdd.12443 BindingDB Entry DOI: 10.7270/Q2FF3R28
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